WHAT IF I LEARN™ LABS
TISSUE ENGINEERING BY HAILEY
CREATING A KIDNEY: HOW STEM CELLS MIGHT BE USED TO BIOENGINEER A VITAL ORGAN
SOLUBLE FACTOR
ABBREVIATED GENE NAME
FAMILY IT BELONGS TO
DOES IT REGULATE PROLIFERATION OR APOPTOSIS
DOES IT REGULATE DIFFERENTIATION
DOES IT REGULATE DEVELOPMENT
DOES IT REGULATE EPITHELIAL-TO-MESENCHYMAL TRANSITION
WHAT OTHER KEY FUNCTIONS DOES IT HAVE
Activin A
Retinoic Acid
Platelet Derived-Growth Factor
Insulin-Like Growth Factor
Transforming Growth Factor Beta
Transforming Growth Factor Alpha
Hepatocyte Growth Factor
WNT4
INHBA
RARA
WNT4
HGF
TGFA
TGFB1
IGF1
PDGFA
enables type II activin receptor binding
TGF-beta superfamily
enables transcription corepressor activity
enables protein binding
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yes, regulates epithelial-to-mesenchymal transition in colon cancer cells
enables collagen binding
enables protein hetero-dimerization activity
yes
yes
yes
yes
enables chemo-attractant activity
yes
yes
yes
yes
WNT gene family
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
EGF family
TGFB superfamily
plasminogen subfamily
yes
yes
yes
nuclear receptor superfamily
ILGF-like superfamily
yes
PDGF superfamily
enables chromatin binding
enables receptor ligand activity
yes
yes
yes
na
na
na
na
yes